Thematic review series: Lipid Posttranslational Modifications. Geranylgeranylation of Rab GTPases
Rab GTPases require special machinery for protein prenylation, which include Rab escort protein (REP) and Rab geranylgeranyl transferase (RGGT).The current model of Rab geranylgeranylation proposes that REP binds Rab and presents it to RGGT.After geranylgeranylation of Rab C-terminal cysteines, REP delivers the prenylated protein to membranes.The R